{"id":628,"date":"2013-03-03T14:09:44","date_gmt":"2013-03-03T05:09:44","guid":{"rendered":"http:\/\/singularities.sfc.keio.ac.jp\/wp\/?page_id=628"},"modified":"2013-03-03T14:24:06","modified_gmt":"2013-03-03T05:24:06","slug":"%e5%8d%98%e7%b4%b0%e8%83%9e%e3%83%a2%e3%83%87%e3%83%ab%e3%81%ab%e5%9f%ba%e3%81%a5%e3%81%8f%e5%a4%9a%e7%b4%b0%e8%83%9e%e7%b5%84%e7%b9%94%e3%83%a2%e3%83%87%e3%83%ab%ef%bc%9a%e8%82%9d%e5%b0%8f%e8%91%89","status":"publish","type":"page","link":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/?page_id=628","title":{"rendered":"\u5358\u7d30\u80de\u30e2\u30c7\u30eb\u306b\u57fa\u3065\u304f\u591a\u7d30\u80de\u7d44\u7e54\u30e2\u30c7\u30eb\uff1a\u809d\u5c0f\u8449\u5185\u306e\u4ee3\u8b1d\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3"},"content":{"rendered":"<table class=\"wpgallery\" border=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>Ohno H, Naito Y, Nakajima H, Tomita M. Construction of a biological tissue\u00a0model based on a single-cell model: a computer simulation of metabolic\u00a0heterogeneity in the liver lobule. Artif Life. 2008 Winter;14(1):3-28. <span class=\"open-access\"><a title=\"Journal Site\" href=\"http:\/\/dx.doi.org\/10.1162\/artl.2008.14.1.3\" target=\"_blank\">Open Access<\/a><\/span> <span class=\"pdf-link\"><a title=\"Journal Site\" href=\"http:\/\/www.mitpressjournals.org\/doi\/pdf\/10.1162\/artl.2008.14.1.3\" target=\"_blank\">PDF<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7d30\u80de\u5185\u306e\u73fe\u8c61\u306b\u3064\u3044\u3066\u5f97\u3089\u308c\u305f\u7406\u89e3\u3092\u500b\u4f53\u30ec\u30d9\u30eb\u3078\u3068\u6577\u884d\u3059\u308b\u4e2d\u9593\u6bb5\u968e\u3068\u3057\u3066\uff0c\u7d44\u7e54\uff0c\u5668\u5b98\u30ec\u30d9\u30eb\u306e\u73fe\u8c61\u306e\u7406\u89e3\u304c\u6b20\u304b\u305b\u306a\u3044\uff0e\u591a\u304f\u306e\u5668\u5b98\uff0c\u7d44\u7e54\u306b\u304a\u3044\u3066\uff0c\u90e8\u4f4d\u3042\u308b\u3044\u306f\u6642\u9593\u7684\u306b\u4e0d\u5747\u8cea\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u305d\u3046\u3057\u305f\u8abf\u7bc0\u304c\u4f55\u306e\u305f\u3081\u306b\u5b58\u5728\u3059\u308b\u306e\u304b\u304c\u5fc5\u305a\u3057\u3082\u660e\u3089\u304b\u3067\u306a\u3044\u4e8b\u4f8b\u306f\u5c11\u306a\u304f\u306a\u3044\uff0e\u307b\u4e73\u985e\u306e\u809d\u81d3\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u306e\u591a\u304f\u306b\u3082\uff0c\u9580\u8108\u9818\u57df\u304b\u3089\u4e2d\u5fc3\u9759\u8108\u9818\u57df\u306b\u304b\u3051\u3066\u4e0d\u5747\u8cea\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0cmetabolic zonation\uff0cmetabolic heterogeneity \u306a\u3069\u3068\u547c\u3070\u308c\u3066\u3044\u308b\uff0e\u809d\u81d3\u3067\u72ec\u5360\u7684\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u9175\u7d20\u306e\u4e00\u90e8\u306b\u3082\uff0c\u3053\u3046\u3057\u305fheterogeneity \u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u79c1\u305f\u3061\u306f\uff0c\u9f67\u6b6f\u985e\u306e\u809d\u7d30\u80de\u306b\u304a\u3051\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u6570\u7406\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u3057\uff0c\u3053\u308c\u306b\u57fa\u3065\u3044\u3066\u809d\u5c0f\u8449\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u305f\uff0e\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fb\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u7d50\u679c\u306f\uff0c\u5b9f\u969b\u306b\u89b3\u5bdf\u3055\u308c\u308b\u7d44\u7e54\u30ec\u30d9\u30eb\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e heterogeneity \u3092\u3088\u304f\u518d\u73fe\u3057\u305f\uff0e\u3053\u306e\u809d\u5c0f\u8449\u30e2\u30c7\u30eb\u3067\u306f\uff0c\u7d44\u7e54\u30ec\u30d9\u30eb\u306e\u4ee3\u8b1d\u3092\u89b3\u5bdf\u3057\u306a\u304c\u3089\uff0c\u540c\u6642\u306b\u500b\u3005\u306e\u7d30\u80de\u5185\u306e\u4ee3\u8b1d\u3092\u8ffd\u8de1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308a\uff0c\u500b\u3005\u306e\u7d30\u80de\u5185\u3067\u306e\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u8abf\u7bc0\u304c\uff0c\u7d44\u7e54\u30ec\u30d9\u30eb\uff08\u809d\u7d30\u8449\uff09\uff0c\u5668\u5b98\u30ec\u30d9\u30eb\uff08\u809d\u81d3\uff09\u3067\u306e\u4ee3\u8b1d\u306b\u3069\u3046\u3044\u3063\u305f\u610f\u7fa9\u3092\u6301\u3064\u304b\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u4e00\u90e8\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u95a2\u9023\u9175\u7d20\u306b\u307f\u3089\u308c\u308b\u809d\u5c0f\u8449\u5185\u90e8\u4f4d\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\uff0c\u9175\u7d20\u6d3b\u6027\u306e\u504f\u308a\u306b\u3088\u3063\u3066\uff0c\u7d44\u7e54\u30ec\u30d9\u30eb\uff0c\u5668\u5b98\u30ec\u30d9\u30eb\u3067\u5408\u7406\u7684\u306a\u5229\u5f97\u304c\u751f\u3058\u3066\u3044\u308b\u306e\u304b\uff0c\u307e\u305f\u305d\u306e\u5229\u5f97\u3068\u3057\u3066\u4f55\u304c\u8003\u3048\u3089\u308c\u308b\u306e\u304b\u3092\u691c\u8a0e\u3057\u305f\uff0e<\/p>\n<h1>\u809d\u81d3\u306e\u7d44\u7e54\u69cb\u9020<\/h1>\n<table class=\"alignright\" style=\"width: 310px;\" border=\"0\">\n<tbody class=\"wp-caption\">\n<tr>\n<td><a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/LiverArchitecture.jpg\" rel=\"lightbox[628]\"><img class=\"size-medium wp-image-631\" title=\"\u56f3\uff11\u3000\u809d\u5c0f\u8449\u306e\u7d44\u7e54\u69cb\u9020\" alt=\"Liver Architecture\" src=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/LiverArchitecture-300x244.jpg\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"wp-caption-text\"><strong>\u56f3\uff11\u3000\u809d\u5c0f\u8449\u306e\u7d44\u7e54\u69cb\u9020<\/strong>\uff1a\u809d\u5c0f\u8449\u3078\u306e\u6d41\u5165\u8840\u7ba1\u306f\uff0c\u809d\u52d5\u8108\u306e\u7d30\u679d\uff08HA\uff09\uff0c\u9580\u8108\u306e\u7d30\u679d\uff08PV\uff09\u3067\u3042\u308b\uff0e\u3053\u308c\u3089\u306e\u8840\u7ba1\u306f\u809d\u5c0f\u8449\u5185\u306b\u5165\u308b\u3068\uff0c\u591a\u5b54\u69cb\u9020\u306e\u7279\u6b8a\u306a\u6bdb\u7d30\u8840\u7ba1\u30fb\u985e\u6d1e\uff08S\uff09\u306b\u679d\u5206\u304b\u308c\u3057\uff0c\u809d\u7d30\u80de\u304c\u9023\u306a\u3063\u305f\u809d\u7d30\u80de\u7d22\uff08H\uff09\u3092\u901a\u904e\u3059\u308b\uff0e\u6700\u5f8c\u306b\u306f\u985e\u6d1e\u3069\u3046\u3057\u304c\u5408\u6d41\u3057\uff0c\u809d\u5c0f\u8449\u306e\u4e2d\u592e\u306b\u4f4d\u7f6e\u3059\u308b\u4e2d\u5fc3\u9759\u8108\uff08CV\uff09\u304b\u3089\u6d41\u51fa\u3059\u308b\uff0e(Sasse D et.al., 1992)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u809d\u81d3\u306f\u591a\u6570\u306e\u4ee3\u8b1d\u3092\u540c\u6642\u4e26\u884c\u306b\u9042\u884c\u3059\u308b\u300c\u5316\u5b66\u5de5\u5834\u300d\u3067\u3042\u308b\uff0e\u4ee3\u8b1d\u306e\u5bfe\u8c61\u3068\u306a\u308b\u7269\u8cea\u306f\u8840\u7ba1\u3092\u4ecb\u3057\u3066\u809d\u81d3\u306b\u5230\u9054\u3059\u308b\uff0e\u809d\u81d3\u306f\u9580\u8108\u7cfb\u3068\u3044\u3046\u5168\u8eab\u306e\u8840\u6db2\u5faa\u74b0\u306e\u4e2d\u3067\u3082\u7279\u6b8a\u306a\u4f4d\u7f6e\u306b\u5b58\u5728\u3059\u308b\uff0e\u901a\u5e38\uff0c\u5fc3\u81d3\u304b\u3089\u62cd\u51fa\u3055\u308c\u305f\u8840\u6db2\u306f\u52d5\u8108\u3092\u901a\u3063\u3066\u5168\u8eab\u306b\u9001\u3089\u308c\uff0c\u6bdb\u7d30\u8840\u7ba1\u306b\u679d\u5206\u304b\u308c\u3057\u3066\u672b\u68a2\u306b\u5206\u5e03\u3059\u308b\uff0e\u6bdb\u7d30\u8840\u7ba1\u306f\u9759\u8108\u306b\u5408\u6d41\u3057\uff0c\u5fc3\u81d3\u306b\u5e30\u3063\u3066\u3044\u304f\uff0e\u4f8b\u5916\u7684\u306b\uff0c\u6bdb\u7d30\u8840\u7ba1\u304c\u5408\u6d41\u3057\u305f\u5f8c\uff0c\u5fc3\u81d3\u306b\u623b\u308b\u3053\u3068\u306a\u304f\u5225\u306e\u5668\u5b98\u306b\u9001\u3089\u308c\u308b\u69cb\u9020\u304c\u307f\u3089\u308c\u308b\uff0e\u3053\u308c\u3092\u9580\u8108\u3068\u547c\u3076\uff0e\u9580\u8108\u3092\u4ecb\u3057\u305f\u5faa\u74b0\u3067\u306f\uff0c\u5fc3\u81d3\u2192\u52d5\u8108\u2192\u5668\u5b98\uff11\u2192\u9580\u8108\u2192\u5668\u5b98\uff12\u2192\u9759\u8108\u2192\u5fc3\u81d3 \u306e\u9806\u306b\u8840\u6db2\u304c\u3081\u3050\u308b\u3053\u3068\u306b\u306a\u308b\uff0e\u54fa\u4e73\u985e\u306e\u8eab\u4f53\u306b\u307f\u3089\u308c\u308b\u9580\u8108\u306f\u305f\u3063\u305f\uff12\u30f6\u6240\u3057\u304b\u306a\u3044\uff0e\u3072\u3068\u3064\u306f\u809d\u81d3\uff0c\u3082\u3046\u3072\u3068\u3064\u306f\u8133\u4e0b\u5782\u4f53\u3067\u3042\u308b\uff0e<br \/>\n\u809d\u81d3\u306f\uff0c\u6d88\u5316\u7ba1\u306b\u5206\u5e03\u3057\u305f\u6bdb\u7d30\u8840\u7ba1\u304c\u5408\u6d41\u3057\u305f\u9580\u8108\u304b\u3089\u306e\u8840\u6db2\u3092\u53d7\u3051\u53d6\u308b\uff0e\u3053\u306e\u69cb\u9020\u306b\u3088\u308a\uff0c\u6d88\u5316\u5668\u3067\u5916\u754c\u304b\u3089\u5438\u53ce\u3057\u305f\u7269\u8cea\u306f\uff0c\u3059\u3079\u3066\u4e00\u65e6\u809d\u81d3\u3092\u901a\u904e\u3059\u308b\uff0e\u305d\u306e\u969b\uff0c\u6bd2\u7269\u306f\u5206\u89e3\u3055\u308c\uff0c\u904e\u5270\u306a\u6804\u990a\u7d20\u306f\u809d\u81d3\u306b\u5099\u84c4\u3055\u308c\u308b\uff0e\u809d\u81d3\u306f\u6d88\u5316\u5438\u53ce\u3057\u305f\u7269\u8cea\u306b\u5bfe\u3059\u308b\u300c\u691c\u75ab\u6240\u300d\u306e\u5f79\u76ee\u3092\u679c\u305f\u3057\u3066\u304a\u308a\uff0c\u809d\u81d3\u306b\u3088\u308b\u691c\u75ab\u3092\u901a\u904e\u3057\u305f\u7269\u8cea\u3060\u3051\u304c\uff0c\u5168\u8eab\u3078\u3068\u9001\u308a\u5c4a\u3051\u3089\u308c\u308b\uff0e<br \/>\n\u3053\u308c\u3068\u306f\u5225\u306b\uff0c\u809d\u52d5\u8108\u3092\u4ecb\u3057\u3066\u5fc3\u81d3\u304b\u3089\u76f4\u63a5\uff0c\u9178\u7d20\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u8840\u6db2\u3082\u53d7\u3051\u53d6\u3063\u3066\u304a\u308a\uff0c\u809d\u81d3\u3078\u306e\u6d41\u5165\u8840\u7ba1\u306f\uff12\u7cfb\u7d71\u3042\u308b\uff0e\u6d41\u51fa\u8840\u7ba1\u306f\u809d\u9759\u8108\uff11\u7cfb\u7d71\u3060\u3051\u3067\u3042\u308b\uff0e<br \/>\n\u809d\u81d3\u306f\uff0c\u809d\u5c0f\u8449\u3068\u547c\u3070\u308c\u308b\u7d44\u7e54\u5358\u4f4d\u306e\u96c6\u5408\u3067\u3042\u308b\uff08\u56f3\uff11\uff09\u305d\u308c\u305e\u308c\u306e\u809d\u5c0f\u8449\u306b\uff0c\u809d\u52d5\u8108\uff0c\u9580\u8108\u306e\u7d30\u679d\u304b\u3089\u8840\u6db2\u304c\u6d41\u5165\u3057\uff0c\u4e2d\u5fc3\u9759\u8108\u3068\u547c\u3070\u308c\u308b\u809d\u9759\u8108\u306e\u7d30\u679d\u304b\u3089\u6d41\u51fa\u3057\u3066\u3044\u304f\uff0e\u3059\u3079\u3066\u306e\u809d\u5c0f\u8449\u306b\u540c\u3058\u7d44\u6210\u306e\u8840\u6db2\u304c\u6d41\u5165\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u305f\u3081\uff0c\u7b49\u3057\u3044\u4ee3\u8b1d\u3092\u5b9f\u884c\u3067\u304d\u308b\u74b0\u5883\u306b\u7f6e\u304b\u308c\u3066\u3044\u308b\uff0e\u809d\u81d3\u306f\u809d\u5c0f\u8449\u306e\u4e26\u5217\u56de\u8def\u3067\u3042\u308b\u3068\u3044\u3048\u308b\uff0e<\/p>\n<h1>\u809d\u5c0f\u8449\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u306e\u4e0d\u5747\u4e00\u6027<\/h1>\n<table class=\"aligncenter\" style=\"width: 550px;\" border=\"0\">\n<tbody class=\"wp-caption\">\n<tr>\n<td><a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/NH3Zonation.jpg\" rel=\"lightbox[628]\"><img loading=\"lazy\" class=\"size-medium wp-image-631\" title=\"\u56f3\uff12\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u4e0d\u5747\u8cea\u6027\" alt=\"Heterogeneity of ammonia metabolism\" src=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/NH3Zonation.jpg\" width=\"540\" height=\"152\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"wp-caption-text\"><strong>\u56f3\uff12\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u4e0d\u5747\u8cea\u6027<\/strong>\uff1a\u809d\u5c0f\u8449\u3067\u306f\uff0c\u9580\u8108\u5074\u3068\u9759\u8108\u5074\u3067\u4ee3\u8b1d\u306e\u52d5\u614b\u304c\u7570\u306a\u308b\uff0e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u5834\u5408\u306b\u3082\uff0c\u4e0a\u6d41\u306b\u3042\u305f\u308b\u9580\u8108\u8fba\u7e01\u9818\u57df periportal zone \u3067\u306f\u5c3f\u7d20\u56de\u8def\u306b\u3088\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u5c3f\u7d20\u3078\u306e\u8ee2\u63db\u304c\u512a\u52e2\u3067\u3042\u308a\uff0c\u4e0b\u6d41\u306b\u5f53\u305f\u308b\u9759\u8108\u8fba\u7e01\u9818\u57df perivenous zone \u3067\u306f glutamine synthetase (GS) \u306b\u3088\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u751f\u6210\u304c\u512a\u52e2\u3067\u3042\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u3046\u3057\u305f\u809d\u5185\u306e\u4f4d\u7f6e\u306b\u3088\u308b\u4ee3\u8b1d\u306e\u4e0d\u5747\u4e00\u6027 heterogeneity \u306f\uff0c\u809d\u5c0f\u8449\u306e\u7d44\u7e54\u5b66\u7684\u69cb\u9020\u304b\u3089\u5fc5\u7136\u7684\u306b\u8d77\u3053\u308b\u52fe\u914d\uff08\u4e00\u822c\u306b\u4e0a\u6d41\u306e\u809d\u7d30\u80de\u306f\u9ad8\u6fc3\u5ea6\u306e\u57fa\u8cea\u306b\u66dd\u3055\u308c\u308b\u7b49\uff09\u3092\u57fa\u76e4\u306b\uff0c\u90e8\u4f4d\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u3082\u52a0\u308f\u3063\u3066\u6210\u7acb\u3057\u3066\u3044\u308b\uff0e(Ohno H et.al., 2008)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u809d\u81d3\u3092\u69cb\u6210\u3059\u308b\u809d\u5c0f\u8449\u304c\u7b49\u4fa1\u3067\u3042\u308b\u4e00\u65b9\uff0c\u809d\u5c0f\u8449\u5185\u90e8\u306e\u4ee3\u8b1d\u306f\u5747\u8cea\u3067\u306f\u3042\u308a\u3048\u306a\u3044\uff0e\u306a\u305c\u306a\u3089\uff0c\u809d\u5c0f\u8449\u5185\u306b\u306f\uff0c\u4e0a\u6d41\uff08\u9580\u8108\u5074\uff09\u3068\u4e0b\u6d41\uff08\u4e2d\u5fc3\u9759\u8108\u5074\uff09\u304c\u3042\u308b\u304b\u3089\u3067\u3042\u308b\uff0e\u3053\u306e\u4e0a\u6d41\u304b\u3089\u4e0b\u6d41\u3078\u306e\u6d41\u308c\u3092 porto-central axis\uff08\u9580\u8108-\u4e2d\u5fc3\u9759\u8108\u8ef8\uff09\u3068\u547c\u3076\uff0e\u4e0a\u6d41\u306b\u306f\uff0c\u809d\u7d30\u80de\u306b\u3088\u308b\u300c\u691c\u75ab\u300d\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u3055\u307e\u3056\u307e\u306a\u7269\u8cea\u304c\u591a\u91cf\u306b\u542b\u307e\u308c\u3066\u3044\u308b\uff0e\u3053\u308c\u306b\u5bfe\u3057\uff0c\u4e0b\u6d41\u306b\u5230\u9054\u3059\u308b\u306e\u306f\uff0c\u3059\u3067\u306b\u4e0a\u6d41\u306e\u809d\u7d30\u80de\u3067\u4ee3\u8b1d\u304c\u9032\u3093\u3060\u300c\u691c\u75ab\u6e08\u307f\u300d\u306e\u8840\u6db2\u3067\u3042\u308b\uff0e\u809d\u7d30\u80de\u306b\u3068\u3063\u3066\uff0c\u96a3\u63a5\u3059\u308b\u985e\u6d1e\u3092\u6d41\u308c\u308b\u8840\u6db2\u306e\u7d44\u6210\u306f\u300c\u5916\u90e8\u74b0\u5883\u300d\u3067\u3042\u308b\uff0ePorto-central axis \u4e0a\u6d41\u306e\u809d\u7d30\u80de\u3068\u4e0b\u6d41\u306e\u809d\u7d30\u80de\u3067\u306f\uff0c\u3053\u306e\u300c\u5916\u90e8\u74b0\u5883\u300d\u306e\u7d44\u6210\u304c\u7570\u306a\u308b\u305f\u3081\uff0c\u540c\u3058\u4ee3\u8b1d\u3092\u884c\u3046\u3053\u3068\u306f\u3067\u304d\u306a\u3044\uff0e\u305f\u3068\u3048\u4e0a\u6d41\u304b\u3089\u4e0b\u6d41\u306b\u304b\u3051\u3066\u306e\u809d\u7d30\u80de\u304c\u307e\u3063\u305f\u304f\u7b49\u3057\u3044\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u3092\u53d7\u3051\u305f\u307e\u3063\u305f\u304f\u7b49\u3057\u3044\u72b6\u614b\u306e\u7d30\u80de\u3067\u3042\u3063\u3066\u3082\uff0c\u7570\u306a\u308b\u74b0\u5883\u4e2d\u306b\u7f6e\u304b\u308c\u308b\u305f\u3081\u306b\uff0c\u7d30\u80de\u5185\u3067\u9032\u884c\u3059\u308b\u4ee3\u8b1d\u306f\u540c\u4e00\u3067\u306f\u3042\u308a\u3048\u306a\u3044\uff0e<br \/>\n\u305d\u306e\u305f\u3081\uff0c\u4ee3\u8b1d\u306e\u4e0d\u5747\u8cea\u6027\uff08metabolic heterogeneity \u3042\u308b\u3044\u306f metabolic zonation\uff09\u304c\u5fc5\u7136\u7684\u306b\u73fe\u308c\u308b\uff0e<br \/>\n\u3042\u3089\u3086\u308b\u4ee3\u8b1d\u7d4c\u8def\u306b\u4e0d\u5747\u8cea\u6027\u304c\u307f\u3089\u308c\u308b\u304c\uff0c\u672c\u7814\u7a76\u3067\u306f\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u5bfe\u8c61\u3068\u3059\u308b\uff0e\u54fa\u4e73\u985e\u3067\u306f\uff0c\u5168\u8eab\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u809d\u81d3\u304c\u4e00\u624b\u306b\u5f15\u304d\u53d7\u3051\u3066\u3044\u308b\uff0e\u305d\u306e\u305f\u3081\uff0c\u809d\u81d3\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u304b\u3089\uff0c\u5168\u8eab\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u307e\u305f\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306b\u3088\u308b\u89e3\u6bd2\u306f\u5fc5\u9808\u306e\u4ee3\u8b1d\u6a5f\u69cb\u3067\u3042\u308a\uff0c\u305d\u306e\u6a5f\u80fd\u4e0d\u5168\u306f\u5c3f\u6bd2\u75c7\u306a\u3069\u306e\u81f4\u6b7b\u7684\u306a\u72b6\u6cc1\u3092\u3082\u305f\u3089\u3059\uff0e<br \/>\n\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u809d\u5185\u306e\u4e0d\u5747\u8cea\u6027\u306b\u3064\u3044\u3066\u56f3\uff12\u306b\u307e\u3068\u3081\u305f\uff0e\u4e0a\u6d41\uff08\u9580\u8108\u5074\uff09\u3067\u306f\u5c3f\u7d20\u56de\u8def\u306b\u3088\u308b\u5c3f\u7d20\u8cdb\u6210\u304c\u512a\u52e2\u3067\uff0c\u4e0b\u6d41\uff08\u4e2d\u5fc3\u9759\u8108\u5074\uff09\u3067\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u5408\u6210\u304c\u512a\u52e2\u3068\u306a\u3063\u3066\u3044\u308b\uff0e\u3053\u306e\u4e0d\u5747\u8cea\u6027\u306e\u8981\u56e0\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u8b70\u8ad6\u304c\u6226\u308f\u3055\u308c\u3066\u3044\u308b\u304c\uff0c\u6c7a\u5b9a\u7684\u306a\u7d50\u8ad6\u306f\u3067\u3066\u3044\u306a\u3044\uff0e<\/p>\n<h1>\u672c\u7814\u7a76\u306e\u76ee\u7684<\/h1>\n<p>\u5c3f\u7d20\u56de\u8def\u306f\u591a\u91cf\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u809d\u5185\u4ee3\u8b1d\u306e\u4e2d\u3067\u3082\uff0c\u6700\u3082\u591a\u304f\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3057\u3066\u3044\u308b\u4ee3\u8b1d\u7d4c\u8def\u306e\u3072\u3068\u3064\u3067\u3042\u308b\uff0e\u30e9\u30c3\u30c8\u809d\u7d30\u80de\u3067\u306f\u70ad\u7d20\u30fb\u7a92\u7d20\u6e90\u306b\u5bcc\u3093\u3060\u57f9\u990a\u6761\u4ef6\u4e0b\u3067\uff0c\u6d88\u8cbb\u3055\u308c\u308b\u5168ATP\u306e\u7d0415%\u304c\u5c3f\u7d20\u751f\u6210\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b(Schneider W et.al., 1990)\uff0e\u8457\u8005\u3089\u306f\uff0cRNA\u5408\u6210\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306b\u6d88\u8cbb\u3055\u308c\u308bATP\u306f\u305d\u308c\u305e\u308c\u7d044%\uff0c13%\u3068\u5831\u544a\u3057\u3066\u3044\u308b\uff0e\u540c\u69d8\u306b\uff0c\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u3082\u6570\u591a\u304f\u306e\u9ad8\u5206\u5b50\u304c\u52d5\u54e1\u3055\u308c\u308b\u9ad8\u5ea6\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u904e\u7a0b\u3067\u3042\u308a\uff0c\u90e8\u4f4d\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u9032\u5316\u3057\uff0cmetabolic zonation \u306b\u5e72\u6e09\u3057\u3066\u3044\u308b\u3053\u3068\u306f\uff0c\u4f55\u3089\u304b\u306e\u5229\u5f97\uff08\u9069\u5fdc\u5ea6\u306e\u5411\u4e0a\uff09\u306b\u3088\u3063\u3066\u88cf\u4ed8\u3051\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u307b\u4e73\u985e\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u89e3\u6bd2\u306f\u5c02\u3089\u809d\u81d3\u3067\u884c\u308f\u308c\u308b\u3082\u306e\u3067\u3042\u308b\u306e\u3067\uff0c\u809d\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306f\u500b\u4f53\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u80fd\u306b\u76f4\u63a5\u53cd\u6620\u3059\u308b\uff0e\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u79c1\u305f\u3061\u306f\uff0c\u6570\u7406\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308a\uff0c\u300c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306b\u307f\u3089\u308c\u308b\u90e8\u4f4d\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u306f\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u5411\u4e0a\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u4f5c\u696d\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u305f\uff0e<\/p>\n<h1>\u809d\u5c0f\u8449\u30e2\u30c7\u30eb<\/h1>\n<table class=\"aligncenter\" style=\"width: 550px;\" border=\"0\">\n<tbody class=\"wp-caption\">\n<tr>\n<td><a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/Model.png\" rel=\"lightbox[628]\"><img loading=\"lazy\" class=\"size-medium wp-image-631\" title=\"\u56f3\uff13\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u30e2\u30c7\u30eb\" alt=\"Heterogeneity of ammonia metabolism\" src=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/Model.png\" width=\"540\" height=\"338\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"wp-caption-text\"><strong>\u56f3\uff13\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u30e2\u30c7\u30eb<\/strong>\uff1a\u809d\u7d30\u80de\u30e2\u30c7\u30eb\u306b\u542b\u307e\u308c\u308b\u4ee3\u8b1d\u7d4c\u8def\uff0e\u3053\u306e\u5916\u5074\u306f\u5b9a\u5e38\u72b6\u614b\u3092\u4eee\u5b9a\u3057\u305f\uff0e\u3059\u3079\u3066\u306e\u53cd\u5fdc\u3092\u5e38\u5fae\u5206\u65b9\u7a0b\u5f0f\u306b\u3088\u308b\u901f\u5ea6\u5f0f\u3067\u8868\u73fe\u3057\u305f\u52d5\u7684\u30e2\u30c7\u30eb\u3067\u3042\u308b\uff0e(Ohno H et.al., 2008)<br \/>\n<span style=\"font-size: xx-small;\">\u7565\u8a9e\uff1aCPS, carbamoylphosphate synthetase I; GS , glutamine synthetase; OAT, Ornithine aminotransferase; AGS, N-acetylglutamate synthetase; GS, Glutamine synthetase; Glnase, phosphate-dependent glutaminase; OCT, ornithine carbamoyltransferase; ASS, argininosuccinate synthetase; ASL, argininosuccinate lyase; Aase, arginase; OAT, ornithine aminotransferase, GOTm, glutamate:oxaloacetate transaminase in mitochondria; GOTc, glutamate:oxaloacetate transaminase in cytoplasm; GDH, glutamate dehydrogenase; GAT, arginine:glycine amidinotransferase; GAMT, guanidinoacetate methyltransferase; OTL, ornithine-citrulline translocase; GTL, glutamate translocase; GATL, glutamate-aspartate translocase; Amm-tra, ammonia transporter; GLT, glutamate transporter; GlnT, glutamine transporter in mitochondrial membrane; UT, urea transporter.<\/span>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u809d\u81d3\u3067\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u9175\u7d20\u53cd\u5fdc\u901f\u5ea6\u8ad6\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u305f\uff0e\u30e2\u30c7\u30eb\u306b\u542b\u307e\u308c\u308b\u8981\u7d20\u3068\u305d\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u56f3\uff13\u306b\u793a\u3057\u305f\uff0e\u3053\u306e\u809d\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u30e2\u30c7\u30eb\u3092\uff11\u3064\u306e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u3068\u3057\uff0c\u3053\u308c\u3092\u76f4\u5217\u306b\uff18\u3064\u9023\u7d50\u3057\u3066\u5358\u7d14\u306a\u809d\u7d30\u8449\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u305f\uff0e\u5404\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u306f\u809d\u5b9f\u8cea\u7d30\u80de\u90e8\u5206\u3068\u985e\u6d1e\u90e8\u5206\u304b\u3089\u306a\u308b\uff0e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u9593\u306e\u7269\u8cea\u306e\u79fb\u52d5\u306f\u985e\u6d1e\u9593\u3067\u306e\u307f\u751f\u3058\uff0c\u4e0a\u6d41\u304b\u3089\u4e0b\u6d41\u306b\u5411\u3051\u3066\u6d41\u308c\u308b mass action \u30e2\u30c7\u30eb\u3067\u8868\u73fe\u3057\u305f\uff08\u809d\u5b9f\u8cea\u7d30\u80de\u9593\u3067\u306e\u7269\u8cea\u79fb\u52d5\uff0c\u985e\u6d1e\u5185\u3067\u306e\u62e1\u6563\uff0c\u5b9f\u8cea\u7d30\u80de\u4ee5\u5916\u306e\u809d\u7d30\u80de\u6a5f\u80fd\u306a\u3069\u306f\u8003\u616e\u3057\u3066\u3044\u306a\u3044\uff09\uff0e<br \/>\n\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u95a2\u9023\u9175\u7d20\u306e\u5c40\u5728\u306f Christoffels \u3089\u306e\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u5b9f\u88c5\u3057\u305f (Christoffels VM et.al., 1999) \uff0ePort-central axis\u306b\u6cbf\u3063\u3066\uff0cCPS, GS, OAT\u306b\u9855\u8457\u306a\u809d\u5c0f\u8449\u5185\u5c40\u5728\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0cCPS \u306f\u9580\u8108\u5468\u8fba\u9818\u57df\u306b\u512a\u52e2\uff0cGS \u306f\u9759\u8108\u5468\u8fba\u9818\u57df\u306b\u512a\u52e2\u306b\u767a\u73fe\u3057\uff0cOAT \u306f GS \u3068 co-localize \u3059\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308b (Kuo FC et.al., 1991) \uff0e\u4eca\u56de\u306f\uff0c\u5c40\u5728\u306e\u6709\u7121\u306e\u7d44\u307f\u5408\u308f\u305b\u3068\u3057\u3066\uff0c\u3059\u3079\u3066\u306e\u5c40\u5728\u3092\u5b9f\u88c5\u3057\u305f GCO \u30e2\u30c7\u30eb\u3068\uff0c\u5c40\u5728\u3092\u307e\u3063\u305f\u304f\u542b\u307e\u306a\u3044 N \u30e2\u30c7\u30eb\u306b\u3064\u3044\u3066\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3044\uff0c\u7d50\u679c\u3092\u691c\u8a0e\u3057\u305f\uff0e<\/p>\n<h1>Metabolic Zonation\u306e\u518d\u73fe\u7d50\u679c<\/h1>\n<table class=\"aligncenter\" style=\"width: 550px;\" border=\"0\">\n<tbody class=\"wp-caption\">\n<tr>\n<td><a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/Nmodel.png\" rel=\"lightbox[628]\"><img loading=\"lazy\" class=\"size-medium wp-image-631\" title=\"\u56f3\uff13\uff21\u3000\uff2e\u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\" alt=\"Heterogeneity of ammonia metabolism\" src=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/Nmodel.png\" width=\"540\" height=\"358\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/GCOmodel.png\" rel=\"lightbox[628]\"><img loading=\"lazy\" class=\"size-medium wp-image-631\" title=\"\u56f3\uff13\uff22\u3000\uff27\uff23\uff2f\u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\" alt=\"Heterogeneity of ammonia metabolism\" src=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/GCOmodel.png\" width=\"540\" height=\"358\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"wp-caption-text\"><strong>\u56f3\uff13\u3000\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c<\/strong>\uff1aGS, CPS, OAT \u306e\u5c40\u5728\u3092\u8003\u616e\u3057\u306a\u3044 N \u30e2\u30c7\u30eb\u3068\uff0c\u8003\u616e\u3057\u305f GCO \u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\uff0e\u3082\u3063\u3068\u3082\u9580\u8108\u5bc4\u308a\u306e\uff11\u756a\u76ee\u306e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u3068\uff0c\u6700\u3082\u9759\u8108\u5bc4\u308a\u306e\uff18\u756a\u76ee\u306e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u306e\u4ee3\u8b1d\u6d41\u91cf\u6bd4\u3092\u7b97\u51fa\u3057\u3066\u4ee3\u8b1d\u7d4c\u8def\u5730\u56f3\u306b\u91cd\u306d\u3066\u3042\u308b\uff0e\u8d64\u306f\uff0c\u9580\u8108\u5468\u8fba\u9818\u57df\u3067\u512a\u52e2\u306a\u53cd\u5fdc\uff0c\u9752\u306f\u9759\u8108\u5468\u8fba\u9818\u57df\u3067\u512a\u52e2\u306a\u53cd\u5fdc\u3067\u3042\u308b\uff0e\u77e2\u5370\u306e\u592a\u3055\u306f\uff0c\u9580\u8108\u301c\u9759\u8108\u9593\u3067\u306e\u8f03\u5dee\u3092\u8868\u3057\uff0c\u77e2\u5370\u304c\u592a\u3044\u307b\u3069\u8f03\u5dee\u304c\u5927\u304d\u3044\uff08\u6700\u3082\u592a\u3044\u77e2\u5370\u3067\uff15\u500d\u4ee5\u4e0a\uff09\uff0e(Ohno H et.al., 2008)\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5c40\u5728\u3092\u8003\u616e\u305b\u305a\uff0c\u307e\u3063\u305f\u304f\u5747\u8cea\u306a\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u304b\u3089\u306a\u308b N \u30e2\u30c7\u30eb\u3067\u306f\uff0c\u9580\u8108\u5468\u8fba\u9818\u57df\u3067\u306f GS \u306b\u3088\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u3078\u306e\u5909\u63db\u304c\u512a\u52e2\u3067\uff0c\u9759\u8108\u5468\u8fba\u9818\u57df\u3067\u306f\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3092 GOT \u306b\u3088\u3063\u3066\u30b0\u30eb\u30bf\u30df\u30f3\u306b\u5909\u63db\u3059\u308b\u7d4c\u8def\u304c\u512a\u52e2\u3060\u3063\u305f\uff0e\u5c3f\u7d20\u751f\u6210\u306b\u95a2\u3057\u3066\u306f\u7279\u8a18\u3059\u3079\u304d\u5dee\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<br \/>\n\u4e00\u65b9\uff0cGCO \u30e2\u30c7\u30eb\u3067\u306f\u9580\u8108\u5468\u8fba\u9818\u57df\u3067\u5c3f\u7d20\u56de\u8def\u3092\u4ecb\u3057\u305f\u5c3f\u7d20\u751f\u6210\u304c\u512a\u52e2\u3067\uff0c\u9759\u8108\u5468\u8fba\u9818\u57df\u3067\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u751f\u6210\u304c\u512a\u52e2\u3068\u306a\u3063\u3066\u304a\u308a\uff0c\u65e2\u77e5\u306eheterogeneity\u3092\u3088\u304f\u518d\u73fe\u3057\u3066\u3044\u308b\uff0e<\/p>\n<table class=\"alignright\" style=\"width: 293px;\" border=\"0\">\n<tbody class=\"wp-caption\">\n<tr>\n<td><a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/Landscape.png\" rel=\"lightbox[628]\"><img class=\"size-medium wp-image-631\" title=\"\u56f3\uff14\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u9069\u5fdc\u5ea6\u5730\u5f62\" alt=\"Liver Architecture\" src=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/wp-content\/uploads\/Landscape-283x300.png\" \/><\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"wp-caption-text\"><strong>\u56f3\uff14\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u9069\u5fdc\u5ea6\u5730\u5f62<\/strong>\uff1a\u30d1\u30e9\u30e1\u30fc\u30bf <em>n<\/em>, <em>K<\/em> \u3092\u5909\u5316\u3055\u305b\uff0c\u5404\u30d1\u30e9\u30e1\u30fc\u30bf\u30bb\u30c3\u30c8\u3067\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u5b9f\u884c\u3057\u305f\uff0e\u9069\u5fdc\u5ea6\u5730\u5f62\u56f3\u306e <em>x<\/em>, <em>y<\/em> \u8ef8\u306f <em>n<\/em>, <em>K<\/em> \u306e\u5024\uff0e<em>z<\/em> \u8ef8\u306f\u30a2\u30f3\u30e2\u30cb\u30a2 1 \u5206\u5b50\u3092\u9664\u53bb\u3059\u308b\u305f\u3081\u306b\u6d88\u8cbb\u3055\u308c\u308b ATP \u5206\u5b50\u6570\uff08\u5c0f\u3055\u3044\u307b\u3069\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u304c\u826f\u3044\uff09\uff0e\u30aa\u30ec\u30f3\u30b8\u8272\u306e\u9818\u57df\u306f\uff0c\u3052\u3063\u6b6f\u985e\u7b49\u3067\u89b3\u5bdf\u3055\u308c\u308b\uff0c\u5b9f\u969b\u306e\u809d\u5c0f\u8449\u5185\u306b\u304a\u3051\u308b\u5c40\u5728\u306b\u76f8\u5f53\u3059\u308b\u72b6\u614b\u3092\u793a\u3059\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4e0a\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\u306b\u3064\u3044\u3066\uff0c\u809d\u7d30\u8449\u5168\u4f53\u3067\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2 1 \u5206\u5b50\u3092\u9664\u53bb\u3059\u308b\u305f\u3081\u306b\u6d88\u8cbb\u3055\u308c\u308b ATP \u5206\u5b50\u6570\u3092\u7b97\u5b9a\u3059\u308b\u3068\uff0cN \u30e2\u30c7\u30eb\u3067\u306f 7.37 \u5206\u5b50\uff0cGCO \u30e2\u30c7\u30eb\u3067\u306f 4.21 \u5206\u5b50\u3067\u3042\u3063\u305f\uff0e\u3053\u3053\u304b\u3089\uff0cGS, CPS, OAT \u306e\u90e8\u4f4d\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u306b\u3088\u3063\u3066\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u3092\u5411\u4e0a\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\uff0e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306f\u809d\u7d30\u80de\u306e ATP \u6d88\u8cbb\u91cf\u306e15%\u3092\u5360\u3081\u3066\u3044\u308b\u306e\u3067\uff0c\u305d\u306e\u52b9\u7387\u304c\u7d04 1.8 \u500d\u306b\u5411\u4e0a\u3059\u308b\u306e\u3067\u3042\u308c\u3070\uff0c\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u305d\u306e\u3082\u306e\u306b\u6d88\u8cbb\u3055\u308c\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u306b\u5341\u5206\u898b\u5408\u3046\u3082\u306e\u3060\u308d\u3046\uff08\u5168 RNA\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306b\u4f7f\u308f\u308c\u308bATP\u3092\u5408\u8a08\u3057\u3066\u3082\u7d04 17% \u7a0b\u5ea6\u3067\u3042\u308b\uff09\uff0e<br \/>\n\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u95a2\u9023\u9175\u7d20\u306e\u809d\u5c0f\u8449\u5185\u3067\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u4e0d\u5747\u8cea\u6027\u304c\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u5411\u4e0a\u306b\u3088\u308b\u9069\u5fdc\u5ea6\u306e\u5411\u4e0a\u306b\u3088\u3063\u3066\u9032\u5316\u3057\u305f\u306e\u3067\u3042\u308c\u3070\uff0c\u305d\u306e\u52b9\u7387\u306f\u3069\u306e\u7a0b\u5ea6\u6700\u9069\u5316\u3055\u308c\u3066\u3044\u308b\u306e\u3060\u308d\u3046\u304b\uff0eChristoffels\u3089\u306e\u30e2\u30c7\u30eb\u3067\u9175\u7d20\u5c40\u5728\u3092\u6c7a\u3081\u308b\u4e3b\u8981\u306a\u30d1\u30e9\u30e1\u30fc\u30bf n, K \u3092\u5909\u5316\u3055\u305b\uff0c\u9069\u5fdc\u5ea6\u5730\u5f62\u3092\u4f5c\u6210\u3057\uff0c\u691c\u8a0e\u3057\u305f\uff08\u56f3\uff14\uff09\uff0e<br \/>\n\u73fe\u5728\u306e\u5c40\u5728\u306f\uff0c\u3053\u306e\u72b6\u614b\u7a7a\u9593\u306e\u4e2d\u3067\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u7684\u306b\u306f\u304b\u306a\u308a\u6700\u9069\u5316\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308b\uff0e\u5404\u72b6\u614b\u306b\u304a\u3051\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u9664\u53bb\u901f\u5ea6\u3092\u691c\u8a0e\u3059\u308b\u3068\uff0c\u73fe\u5728\u306e\u72b6\u6cc1\u4ee5\u4e0a\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u9ad8\u3044\u70b9\u3067\u306f\uff0c\u305d\u308c\u3068\u5f15\u304d\u63db\u3048\u306b\u30a2\u30f3\u30e2\u30cb\u30a2\u9664\u53bb\u901f\u5ea6\u304c\u4f4e\u4e0b\u3057\uff0c\u9069\u5fdc\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\uff0e<br \/>\n\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u3068\u4ee3\u8b1d\u901f\u5ea6\uff0c\u3055\u3089\u306b\u91cd\u70ad\u9178\u30a4\u30aa\u30f3\u306e\u6d88\u8cbb\u306a\u3069\u306e trade-off \u306b\u3088\u3063\u3066\u6700\u9069\u306a\u9175\u7d20\u5c40\u5728\u304c\u6c7a\u307e\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\uff0c\u4eca\u5f8c\uff0c\u3055\u3089\u306b\u691c\u8a0e\u3092\u8981\u3059\u308b\uff0e<\/p>\n<h1>\u3080\u3059\u3073\uff1aSingularity \u3068\u306e\u95a2\u308f\u308a<\/h1>\n<p>\uff18\u533a\u753b\u306e\u5358\u7d14\u306a\u30e2\u30c7\u30eb\u3067\uff0c\u809d\u81d3\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u4e0d\u5747\u8cea\u6027\u3092\u6982\u306d\u518d\u73fe\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\uff0e<br \/>\n\u307e\u305f\uff0c\u73fe\u884c\u306e\u907a\u4f1d\u5b50\u6d3b\u6027\u306e\u8abf\u7bc0\u306f\uff0c\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u3092\u9ad8\u3081\u308b\u65b9\u5411\u306b\u9069\u5fdc\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\uff0e<br \/>\n\u809d\u81d3\u304c\u809d\u5c0f\u8449\u306e\u4e26\u5217\u56de\u8def\u3068\u3057\u3066\u5b9f\u88c5\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u306f\uff0c\u54fa\u4e73\u985e\u306b\u5171\u901a\u3057\u305f singularity \u3067\u3042\u308b\uff0e\u4ed6\u306e\u3014\u30c7\u30b6\u30a4\u30f3\u3015\u3082\u53ef\u80fd\u3060\u3063\u305f\u306f\u305a\u306a\u306e\u306b\uff0c\u306a\u305c\u3053\u306e\u3014\u30c7\u30b6\u30a4\u30f3\u3015\u3092\u9078\u3093\u3060\u306e\u304b\u3068\u3044\u3046\u554f\u3044\u306f singularity \u306e\u554f\u3044\u3067\u3042\u308b\uff0e\u809d\u5c0f\u8449\u306e\u30b5\u30a4\u30ba\u3084\uff0c\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u3082\u307e\u305f sigularity \u3068\u3044\u3048\u308b\uff0e<br \/>\n\u3053\u308c\u3089\uff0c\u809d\u81d3\u306b\u307f\u3089\u308c\u308b\u968e\u5c64\u7684\u7d44\u7e54\u304a\u3088\u3073\u5236\u5fa1\u69cb\u9020\u306e singularity \u304c deterministic necessity \u3067\u306a\u3044\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b\uff0e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u3092\u9ad8\u3081\u308b\u65b9\u5411\u306b\u6700\u9069\u5316\u304c\u9032\u3093\u3067\u3044\u308b\u3053\u3068\u304b\u3089\uff0cselective bottleneck \u306e\u4f5c\u7528\u304c\u793a\u5506\u3055\u308c\u308b\u304c\uff0c\u4e00\u65b9\u3067\uff0c\u6975\u9650\u307e\u3067\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3068\u3057\u305f\u3089\uff0crestrictive bottleneck \u306e\u62d8\u675f\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308b\uff0e<br \/>\n\u3055\u3089\u306b\u8b70\u8ad6\u3092\u9032\u3081\u308b\u305f\u3081\u306b\u306f\uff0c\u809d\u81d3\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u5b9f\u884c\u3059\u308b\u3014\u53ef\u80fd\u30c7\u30b6\u30a4\u30f3\u7fa4\u3015\u306b\u3064\u3044\u3066\uff0c\u3088\u308a\u591a\u304f\u306e\u63a2\u7d22\u3092\u9032\u3081\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e<\/p>\n<h3>References<\/h3><ul><li style=\"text-indent:-30px; padding: 3px 0 3px 30px\">Christoffels VM et.al., 1999. A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver, <em>Hepatology<\/em>, <em>29<\/em>((4)): 1180-92.<\/li><li style=\"text-indent:-30px; padding: 3px 0 3px 30px\">Kuo FC et.al., 1991. Colocalization in pericentral hepatocytes in adult mice and similarity in developmental expression pattern of ornithine aminotransferase and glutamine synthetase mRNA, <em>Proc Natl Acad Sci U S A<\/em>, <em>88<\/em>((21)): 9468-72.<\/li><li style=\"text-indent:-30px; padding: 3px 0 3px 30px\">Ohno H et.al., 2008. Construction of a biological tissue model based on a single-cell model: a computer simulation of metabolic heterogeneity in the liver lobule, <em>Artif Life<\/em>, <em>14<\/em>((1)): 3-28.<\/li><li style=\"text-indent:-30px; padding: 3px 0 3px 30px\">Sasse D et.al., 1992. Liver architecture, <em>Enzyme<\/em>, <em>46<\/em>((1-3)): 8-32.<\/li><li style=\"text-indent:-30px; padding: 3px 0 3px 30px\">Schneider W et.al., 1990. Balancing of energy-consuming processes of rat hepatocytes, <em>Cell Biochem Funct<\/em>, <em>8<\/em>((4)): 227-32.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Ohno H, Naito Y, Nakajima H, Tomita M. Construction of a biological tissue\u00a0model based on a single-cell model: a computer simulation of metabolic\u00a0heterogeneity in the liver lobule. Artif Life. 2008 Winter;14(1):3-28. Open Access PDF \u7d30\u80de\u5185\u306e\u73fe\u8c61\u306b\u3064\u3044\u3066\u5f97\u3089\u308c\u305f\u7406\u89e3\u3092\u500b\u4f53\u30ec\u30d9\u30eb\u3078\u3068\u6577\u884d\u3059\u308b\u4e2d\u9593\u6bb5\u968e\u3068\u3057\u3066\uff0c\u7d44\u7e54\uff0c\u5668\u5b98\u30ec\u30d9\u30eb\u306e\u73fe\u8c61\u306e\u7406\u89e3\u304c\u6b20\u304b\u305b\u306a\u3044\uff0e\u591a\u304f\u306e\u5668\u5b98\uff0c\u7d44\u7e54\u306b\u304a\u3044\u3066\uff0c\u90e8\u4f4d\u3042\u308b\u3044\u306f\u6642\u9593\u7684\u306b\u4e0d\u5747\u8cea\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u305d\u3046\u3057\u305f\u8abf\u7bc0\u304c\u4f55\u306e\u305f\u3081\u306b\u5b58\u5728\u3059\u308b\u306e\u304b\u304c\u5fc5\u305a\u3057\u3082\u660e\u3089\u304b\u3067\u306a\u3044\u4e8b\u4f8b\u306f\u5c11\u306a\u304f\u306a\u3044\uff0e\u307b\u4e73\u985e\u306e\u809d\u81d3\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u306e\u591a\u304f\u306b\u3082\uff0c\u9580\u8108\u9818\u57df\u304b\u3089\u4e2d\u5fc3\u9759\u8108\u9818\u57df\u306b\u304b\u3051\u3066\u4e0d\u5747\u8cea\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\uff0cmetabolic zonation\uff0cmetabolic heterogeneity \u306a\u3069\u3068\u547c\u3070\u308c\u3066\u3044\u308b\uff0e\u809d\u81d3\u3067\u72ec\u5360\u7684\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u9175\u7d20\u306e\u4e00\u90e8\u306b\u3082\uff0c\u3053\u3046\u3057\u305fheterogeneity \u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u79c1\u305f\u3061\u306f\uff0c\u9f67\u6b6f\u985e\u306e\u809d\u7d30\u80de\u306b\u304a\u3051\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u6570\u7406\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u3057\uff0c\u3053\u308c\u306b\u57fa\u3065\u3044\u3066\u809d\u5c0f\u8449\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u305f\uff0e\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fb\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u7d50\u679c\u306f\uff0c\u5b9f\u969b\u306b\u89b3\u5bdf\u3055\u308c\u308b\u7d44\u7e54\u30ec\u30d9\u30eb\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e heterogeneity 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\u809d\u81d3\u306f\uff0c\u809d\u5c0f\u8449\u3068\u547c\u3070\u308c\u308b\u7d44\u7e54\u5358\u4f4d\u306e\u96c6\u5408\u3067\u3042\u308b\uff08\u56f3\uff11\uff09\u305d\u308c\u305e\u308c\u306e\u809d\u5c0f\u8449\u306b\uff0c\u809d\u52d5\u8108\uff0c\u9580\u8108\u306e\u7d30\u679d\u304b\u3089\u8840\u6db2\u304c\u6d41\u5165\u3057\uff0c\u4e2d\u5fc3\u9759\u8108\u3068\u547c\u3070\u308c\u308b\u809d\u9759\u8108\u306e\u7d30\u679d\u304b\u3089\u6d41\u51fa\u3057\u3066\u3044\u304f\uff0e\u3059\u3079\u3066\u306e\u809d\u5c0f\u8449\u306b\u540c\u3058\u7d44\u6210\u306e\u8840\u6db2\u304c\u6d41\u5165\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u305f\u3081\uff0c\u7b49\u3057\u3044\u4ee3\u8b1d\u3092\u5b9f\u884c\u3067\u304d\u308b\u74b0\u5883\u306b\u7f6e\u304b\u308c\u3066\u3044\u308b\uff0e\u809d\u81d3\u306f\u809d\u5c0f\u8449\u306e\u4e26\u5217\u56de\u8def\u3067\u3042\u308b\u3068\u3044\u3048\u308b\uff0e \u809d\u5c0f\u8449\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u306e\u4e0d\u5747\u4e00\u6027 \u56f3\uff12\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u4e0d\u5747\u8cea\u6027\uff1a\u809d\u5c0f\u8449\u3067\u306f\uff0c\u9580\u8108\u5074\u3068\u9759\u8108\u5074\u3067\u4ee3\u8b1d\u306e\u52d5\u614b\u304c\u7570\u306a\u308b\uff0e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u5834\u5408\u306b\u3082\uff0c\u4e0a\u6d41\u306b\u3042\u305f\u308b\u9580\u8108\u8fba\u7e01\u9818\u57df periportal zone \u3067\u306f\u5c3f\u7d20\u56de\u8def\u306b\u3088\u308b\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u5c3f\u7d20\u3078\u306e\u8ee2\u63db\u304c\u512a\u52e2\u3067\u3042\u308a\uff0c\u4e0b\u6d41\u306b\u5f53\u305f\u308b\u9759\u8108\u8fba\u7e01\u9818\u57df perivenous zone \u3067\u306f glutamine synthetase (GS) \u306b\u3088\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u751f\u6210\u304c\u512a\u52e2\u3067\u3042\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\uff0e\u3053\u3046\u3057\u305f\u809d\u5185\u306e\u4f4d\u7f6e\u306b\u3088\u308b\u4ee3\u8b1d\u306e\u4e0d\u5747\u4e00\u6027 heterogeneity \u306f\uff0c\u809d\u5c0f\u8449\u306e\u7d44\u7e54\u5b66\u7684\u69cb\u9020\u304b\u3089\u5fc5\u7136\u7684\u306b\u8d77\u3053\u308b\u52fe\u914d\uff08\u4e00\u822c\u306b\u4e0a\u6d41\u306e\u809d\u7d30\u80de\u306f\u9ad8\u6fc3\u5ea6\u306e\u57fa\u8cea\u306b\u66dd\u3055\u308c\u308b\u7b49\uff09\u3092\u57fa\u76e4\u306b\uff0c\u90e8\u4f4d\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u3082\u52a0\u308f\u3063\u3066\u6210\u7acb\u3057\u3066\u3044\u308b\uff0e \u809d\u81d3\u3092\u69cb\u6210\u3059\u308b\u809d\u5c0f\u8449\u304c\u7b49\u4fa1\u3067\u3042\u308b\u4e00\u65b9\uff0c\u809d\u5c0f\u8449\u5185\u90e8\u306e\u4ee3\u8b1d\u306f\u5747\u8cea\u3067\u306f\u3042\u308a\u3048\u306a\u3044\uff0e\u306a\u305c\u306a\u3089\uff0c\u809d\u5c0f\u8449\u5185\u306b\u306f\uff0c\u4e0a\u6d41\uff08\u9580\u8108\u5074\uff09\u3068\u4e0b\u6d41\uff08\u4e2d\u5fc3\u9759\u8108\u5074\uff09\u304c\u3042\u308b\u304b\u3089\u3067\u3042\u308b\uff0e\u3053\u306e\u4e0a\u6d41\u304b\u3089\u4e0b\u6d41\u3078\u306e\u6d41\u308c\u3092 porto-central axis\uff08\u9580\u8108-\u4e2d\u5fc3\u9759\u8108\u8ef8\uff09\u3068\u547c\u3076\uff0e\u4e0a\u6d41\u306b\u306f\uff0c\u809d\u7d30\u80de\u306b\u3088\u308b\u300c\u691c\u75ab\u300d\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u3055\u307e\u3056\u307e\u306a\u7269\u8cea\u304c\u591a\u91cf\u306b\u542b\u307e\u308c\u3066\u3044\u308b\uff0e\u3053\u308c\u306b\u5bfe\u3057\uff0c\u4e0b\u6d41\u306b\u5230\u9054\u3059\u308b\u306e\u306f\uff0c\u3059\u3067\u306b\u4e0a\u6d41\u306e\u809d\u7d30\u80de\u3067\u4ee3\u8b1d\u304c\u9032\u3093\u3060\u300c\u691c\u75ab\u6e08\u307f\u300d\u306e\u8840\u6db2\u3067\u3042\u308b\uff0e\u809d\u7d30\u80de\u306b\u3068\u3063\u3066\uff0c\u96a3\u63a5\u3059\u308b\u985e\u6d1e\u3092\u6d41\u308c\u308b\u8840\u6db2\u306e\u7d44\u6210\u306f\u300c\u5916\u90e8\u74b0\u5883\u300d\u3067\u3042\u308b\uff0ePorto-central axis \u4e0a\u6d41\u306e\u809d\u7d30\u80de\u3068\u4e0b\u6d41\u306e\u809d\u7d30\u80de\u3067\u306f\uff0c\u3053\u306e\u300c\u5916\u90e8\u74b0\u5883\u300d\u306e\u7d44\u6210\u304c\u7570\u306a\u308b\u305f\u3081\uff0c\u540c\u3058\u4ee3\u8b1d\u3092\u884c\u3046\u3053\u3068\u306f\u3067\u304d\u306a\u3044\uff0e\u305f\u3068\u3048\u4e0a\u6d41\u304b\u3089\u4e0b\u6d41\u306b\u304b\u3051\u3066\u306e\u809d\u7d30\u80de\u304c\u307e\u3063\u305f\u304f\u7b49\u3057\u3044\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u3092\u53d7\u3051\u305f\u307e\u3063\u305f\u304f\u7b49\u3057\u3044\u72b6\u614b\u306e\u7d30\u80de\u3067\u3042\u3063\u3066\u3082\uff0c\u7570\u306a\u308b\u74b0\u5883\u4e2d\u306b\u7f6e\u304b\u308c\u308b\u305f\u3081\u306b\uff0c\u7d30\u80de\u5185\u3067\u9032\u884c\u3059\u308b\u4ee3\u8b1d\u306f\u540c\u4e00\u3067\u306f\u3042\u308a\u3048\u306a\u3044\uff0e \u305d\u306e\u305f\u3081\uff0c\u4ee3\u8b1d\u306e\u4e0d\u5747\u8cea\u6027\uff08metabolic heterogeneity \u3042\u308b\u3044\u306f metabolic zonation\uff09\u304c\u5fc5\u7136\u7684\u306b\u73fe\u308c\u308b\uff0e \u3042\u3089\u3086\u308b\u4ee3\u8b1d\u7d4c\u8def\u306b\u4e0d\u5747\u8cea\u6027\u304c\u307f\u3089\u308c\u308b\u304c\uff0c\u672c\u7814\u7a76\u3067\u306f\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u5bfe\u8c61\u3068\u3059\u308b\uff0e\u54fa\u4e73\u985e\u3067\u306f\uff0c\u5168\u8eab\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u809d\u81d3\u304c\u4e00\u624b\u306b\u5f15\u304d\u53d7\u3051\u3066\u3044\u308b\uff0e\u305d\u306e\u305f\u3081\uff0c\u809d\u81d3\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u304b\u3089\uff0c\u5168\u8eab\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u307e\u305f\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306b\u3088\u308b\u89e3\u6bd2\u306f\u5fc5\u9808\u306e\u4ee3\u8b1d\u6a5f\u69cb\u3067\u3042\u308a\uff0c\u305d\u306e\u6a5f\u80fd\u4e0d\u5168\u306f\u5c3f\u6bd2\u75c7\u306a\u3069\u306e\u81f4\u6b7b\u7684\u306a\u72b6\u6cc1\u3092\u3082\u305f\u3089\u3059\uff0e \u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u809d\u5185\u306e\u4e0d\u5747\u8cea\u6027\u306b\u3064\u3044\u3066\u56f3\uff12\u306b\u307e\u3068\u3081\u305f\uff0e\u4e0a\u6d41\uff08\u9580\u8108\u5074\uff09\u3067\u306f\u5c3f\u7d20\u56de\u8def\u306b\u3088\u308b\u5c3f\u7d20\u8cdb\u6210\u304c\u512a\u52e2\u3067\uff0c\u4e0b\u6d41\uff08\u4e2d\u5fc3\u9759\u8108\u5074\uff09\u3067\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u5408\u6210\u304c\u512a\u52e2\u3068\u306a\u3063\u3066\u3044\u308b\uff0e\u3053\u306e\u4e0d\u5747\u8cea\u6027\u306e\u8981\u56e0\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u8b70\u8ad6\u304c\u6226\u308f\u3055\u308c\u3066\u3044\u308b\u304c\uff0c\u6c7a\u5b9a\u7684\u306a\u7d50\u8ad6\u306f\u3067\u3066\u3044\u306a\u3044\uff0e \u672c\u7814\u7a76\u306e\u76ee\u7684 \u5c3f\u7d20\u56de\u8def\u306f\u591a\u91cf\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u809d\u5185\u4ee3\u8b1d\u306e\u4e2d\u3067\u3082\uff0c\u6700\u3082\u591a\u304f\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3057\u3066\u3044\u308b\u4ee3\u8b1d\u7d4c\u8def\u306e\u3072\u3068\u3064\u3067\u3042\u308b\uff0e\u30e9\u30c3\u30c8\u809d\u7d30\u80de\u3067\u306f\u70ad\u7d20\u30fb\u7a92\u7d20\u6e90\u306b\u5bcc\u3093\u3060\u57f9\u990a\u6761\u4ef6\u4e0b\u3067\uff0c\u6d88\u8cbb\u3055\u308c\u308b\u5168ATP\u306e\u7d0415%\u304c\u5c3f\u7d20\u751f\u6210\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b\uff0e\u8457\u8005\u3089\u306f\uff0cRNA\u5408\u6210\uff0c\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306b\u6d88\u8cbb\u3055\u308c\u308bATP\u306f\u305d\u308c\u305e\u308c\u7d044%\uff0c13%\u3068\u5831\u544a\u3057\u3066\u3044\u308b\uff0e\u540c\u69d8\u306b\uff0c\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u3082\u6570\u591a\u304f\u306e\u9ad8\u5206\u5b50\u304c\u52d5\u54e1\u3055\u308c\u308b\u9ad8\u5ea6\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u904e\u7a0b\u3067\u3042\u308a\uff0c\u90e8\u4f4d\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u9032\u5316\u3057\uff0cmetabolic zonation \u306b\u5e72\u6e09\u3057\u3066\u3044\u308b\u3053\u3068\u306f\uff0c\u4f55\u3089\u304b\u306e\u5229\u5f97\uff08\u9069\u5fdc\u5ea6\u306e\u5411\u4e0a\uff09\u306b\u3088\u3063\u3066\u88cf\u4ed8\u3051\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u307b\u4e73\u985e\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u89e3\u6bd2\u306f\u5c02\u3089\u809d\u81d3\u3067\u884c\u308f\u308c\u308b\u3082\u306e\u3067\u3042\u308b\u306e\u3067\uff0c\u809d\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306f\u500b\u4f53\u306e\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u80fd\u306b\u76f4\u63a5\u53cd\u6620\u3059\u308b\uff0e\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u79c1\u305f\u3061\u306f\uff0c\u6570\u7406\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308a\uff0c\u300c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306b\u307f\u3089\u308c\u308b\u90e8\u4f4d\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u306f\uff0c\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u5411\u4e0a\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u4f5c\u696d\u4eee\u8aac\u3092\u691c\u8a3c\u3057\u305f\uff0e \u809d\u5c0f\u8449\u30e2\u30c7\u30eb \u56f3\uff13\u3000\u30a2\u30f3\u30e2\u30cb\u30a2\u4ee3\u8b1d\u30e2\u30c7\u30eb\uff1a\u809d\u7d30\u80de\u30e2\u30c7\u30eb\u306b\u542b\u307e\u308c\u308b\u4ee3\u8b1d\u7d4c\u8def\uff0e\u3053\u306e\u5916\u5074\u306f\u5b9a\u5e38\u72b6\u614b\u3092\u4eee\u5b9a\u3057\u305f\uff0e\u3059\u3079\u3066\u306e\u53cd\u5fdc\u3092\u5e38\u5fae\u5206\u65b9\u7a0b\u5f0f\u306b\u3088\u308b\u901f\u5ea6\u5f0f\u3067\u8868\u73fe\u3057\u305f\u52d5\u7684\u30e2\u30c7\u30eb\u3067\u3042\u308b\uff0e \u7565\u8a9e\uff1aCPS, carbamoylphosphate synthetase I; GS , glutamine synthetase; OAT, Ornithine aminotransferase; AGS, N-acetylglutamate synthetase; GS, Glutamine synthetase; Glnase, phosphate-dependent glutaminase; OCT, ornithine carbamoyltransferase; ASS, argininosuccinate synthetase; ASL, argininosuccinate lyase; Aase, &hellip; <a href=\"https:\/\/singularities.sfc.keio.ac.jp\/wp\/?page_id=628\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":588,"menu_order":2,"comment_status":"closed","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/pages\/628"}],"collection":[{"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=628"}],"version-history":[{"count":44,"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/pages\/628\/revisions"}],"predecessor-version":[{"id":685,"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/pages\/628\/revisions\/685"}],"up":[{"embeddable":true,"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=\/wp\/v2\/pages\/588"}],"wp:attachment":[{"href":"https:\/\/singularities.sfc.keio.ac.jp\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}